Dai Y R
Zhonghua Bing Li Xue Za Zhi. 1989 Dec;18(4):296-8.
Nasopharyngeal carcinoma (NPC) and malignant lymphoma are common malignant tumors which frequently involve nasopharynx and cervical lymph nodes. Sometimes, it is difficult to distinguish poorly-differentiated NPC, especially undifferentiated NPC, from malignant lymphoma. Paraffin sections of 221 cases of poorly differentiated or undifferentiated NPC and malignant lymphomas were analysed by immunohistochemical techniques (IGSS, ABC, double stain, etc.), The immunohistochemical criteria of differential diagnosis between NPC and malignant lymphomas were proposed and with these criteria, 40 cases which were difficult to distinguish between NPC and malignant lymphoma were identified. In comparison with the methods of SPA, PAP, ABC, IGSS, etc., and the probes of Ke, EMA, LCA, Vi, etc. on paraffin sections, IGSS or ABC method and probes of Ke and LCA were considered to be more sensitive.
鼻咽癌（NPC）和恶性淋巴瘤是常见的恶性肿瘤，常累及鼻咽部和颈部淋巴结。有时，难以将低分化鼻咽癌，尤其是未分化鼻咽癌与恶性淋巴瘤区分开来。采用免疫组织化学技术（IGSS、ABC、双重染色等）对221例低分化或未分化鼻咽癌及恶性淋巴瘤的石蜡切片进行分析，提出了鼻咽癌与恶性淋巴瘤鉴别诊断的免疫组织化学标准，并依据这些标准确定了40例难以区分鼻咽癌与恶性淋巴瘤的病例。与SPA、PAP、ABC、IGSS等方法以及石蜡切片上的Ke、EMA、LCA、Vi等探针相比，IGSS或ABC方法以及Ke和LCA探针被认为更敏感。
