Comella C L, Goetz C G
Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.
Mov Disord. 1994 Sep;9(5):545-9. doi: 10.1002/mds.870090507.
This study evaluated the prevalence and clinical characteristics of akathisia in a tertiary care Parkinson's disease (PD) practice, and assessed the agreement between investigators for the diagnosis of akathisia in PD, and the sensitivity and specificity of a brief patient questionnaire. Fifty-six consecutive PD patients completed an akathisia questionnaire and then were clinically evaluated for akathisia by two examiners blinded to the patient questionnaire. Overall, 45% of PD patients had akathisia as determined by clinical evaluation. Interrater reliability for the diagnosis of akathisia was high (K = 0.89). Patient self-report of restlessness agreed with examiner diagnosis in 89% of the patients. The presence of akathisia was associated with the severity and age of onset of PD. Symptoms most frequently affected the legs, and associated movements were suppressible for brief periods.
本研究评估了三级医疗帕金森病（PD）诊疗机构中静坐不能的患病率及临床特征，评估了研究人员之间对PD患者静坐不能诊断的一致性，以及一份简短患者问卷的敏感性和特异性。56例连续的PD患者完成了一份静坐不能问卷，然后由两名对患者问卷不知情的检查者对其进行静坐不能的临床评估。总体而言，经临床评估确定45%的PD患者存在静坐不能。静坐不能诊断的检查者间信度较高（K = 0.89）。89%的患者中，患者对坐立不安的自我报告与检查者的诊断一致。静坐不能的存在与PD的严重程度和发病年龄相关。症状最常累及腿部，相关动作可在短时间内被抑制。
