突触后受体局部阻断诱导的长期突触丧失
Long-term synapse loss induced by focal blockade of postsynaptic receptors.
作者信息
Balice-Gordon R J, Lichtman J W
机构信息
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110.
出版信息
Nature. 1994 Dec 8;372(6506):519-24. doi: 10.1038/372519a0.
DOI:10.1038/372519a0
PMID:7990923
Abstract
Focal application in vivo of alpha-bungarotoxin to block neurotransmission in a small region of a neuromuscular junction causes long-lasting synapse elimination at that site. In contrast, blockade of neurotransmission throughout a junction does not cause synapse elimination. These and related experiments indicate that active synaptic sites can destabilize inactive synapses in their vicinity.
摘要
在体内局部应用α-银环蛇毒素以阻断神经肌肉接头小区域内的神经传递，会导致该部位长期的突触消除。相比之下，阻断整个接头的神经传递并不会导致突触消除。这些及相关实验表明，活跃的突触位点会使其附近不活跃的突触变得不稳定。
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