Aufricht C, Ties M, Wimmer M, Haschke F, Pietschnig B, Herkner K
Universitäts-Kinderklinik, University of Vienna, Austria.
Pediatr Cardiol. 1994 Jul-Aug;15(4):167-9. doi: 10.1007/BF00800670.
A controlled study was carried out to evaluate the effects of postoperative iron therapy on iron status in anemic children after cardiopulmonary bypass. The patients were 8 boys and 9 girls (mean age 6.5 years) who underwent elective closure of atrial septal defect, secundum type. On postoperative day 9, patients were randomly assigned to either iron supplementation with iron sulfate 5 mg/kg until day 56 or to a control group. Hemoglobin, reticulocytes, transferrin saturation, free erythrocyte protoporphyrin, and ferritin were measured, the final outcome measure being postoperative iron status on day 56. The treatment group showed higher transferrin saturations (33.5% versus 18.0%), smaller decreases in ferritin level (+3.0 versus--13.7 ng/ml), and a lower incidence of depleted iron stores (0/8 versus 5/9) than the control group (all data: P < 0.05). Anemic children after cardiopulmonary bypass for surgical repair of congenital heart disease thus benefit from iron supplementation within the first postoperative weeks.
开展了一项对照研究，以评估术后铁剂治疗对体外循环后贫血儿童铁状态的影响。患者为8名男孩和9名女孩（平均年龄6.5岁），他们接受了继发孔型房间隔缺损的择期闭合手术。术后第9天，患者被随机分为两组，一组补充硫酸亚铁5mg/kg直至第56天，另一组为对照组。测量了血红蛋白、网织红细胞、转铁蛋白饱和度、游离红细胞原卟啉和铁蛋白，最终结局指标为第56天的术后铁状态。与对照组相比，治疗组的转铁蛋白饱和度更高（33.5%对18.0%），铁蛋白水平下降幅度更小（+3.0对-13.7ng/ml），铁储备耗尽的发生率更低（0/8对5/9）（所有数据：P<0.05）。因此，先天性心脏病手术修复体外循环后的贫血儿童在术后第一周内补充铁剂有益。
