对大脑结构异常与精神分裂症家族史之间关系的重新审视。

A reconsideration of the relationship between cerebral structural abnormalities and family history of schizophrenia.

作者信息

Vita A, Dieci M, Giobbio G M, Garbarini M, Morganti C, Braga M, Invernizzi G

机构信息

Psychiatry Unit, Institute of Psychiatry, University of Milan, Italy.

出版信息

Psychiatry Res. 1994 Jul;53(1):41-55. doi: 10.1016/0165-1781(94)90094-9.

DOI:10.1016/0165-1781(94)90094-9

PMID:7991731

Abstract

In a study of 229 schizophrenic patients for whom reliable family history information was available, ventricular size and incidence of ventricular enlargement were found to be greater in male cases without a family history of schizophrenia. A significant sex by family history interaction on cerebral ventricular dimension was detected. The age-corrected morbid risk for schizophrenia was lower among first degree relatives of male probands with ventricular enlargement vs. those with normal ventricles, but similar in relatives of females with and without ventricular enlargement. On the other hand, no association was found between family history and degree of cortical atrophy. A meta-analysis of published studies on the issue revealed 20% larger ventricles in patients without any known genetic predisposition for schizophrenia.

摘要

在一项针对229例有可靠家族史信息的精神分裂症患者的研究中，发现无精神分裂症家族史的男性病例的脑室大小和脑室扩大发生率更高。检测到家族史与性别对脑室大小存在显著交互作用。与脑室正常的男性先证者的一级亲属相比，脑室扩大的男性先证者的一级亲属经年龄校正后的精神分裂症发病风险较低，但女性有或无脑室扩大的亲属的发病风险相似。另一方面，未发现家族史与皮质萎缩程度之间存在关联。对关于该问题的已发表研究进行的荟萃分析显示，无任何已知精神分裂症遗传易感性的患者脑室大20%。