磷脂酶A2及脂皮质素（膜联蛋白）I、II和V在人胎膜和胎盘中的表达与分娩的关系

The expression of phospholipase A2 and lipocortins (annexins) I, II and V in human fetal membranes and placenta in association with labour.

作者信息

Bennett P, Slater D, Berger L, Moor G

机构信息

Action Research Laboratory for the Molecular Biology of Fetal Development, Royal Post Graduate Medical School, London, England.

出版信息

Prostaglandins. 1994 Aug;48(2):81-90. doi: 10.1016/0090-6980(94)90086-8.

DOI:10.1016/0090-6980(94)90086-8

PMID:7991777

Abstract

We have studied the expression of the cellular, type two phospholipase A2 and lipocortins (annexins) I, II and V in human amnion, chorion-decidua and placenta using northern analysis. We found no difference in the expression of phospholipase A2 or lipocortin V in tissues obtained before or after labour. Lipocortin I expression was found to decrease in amnion and placenta but increase in chorion decidua with the onset of labour, while expression of lipocortin II increased only in amnion. These results support the hypothesis that the increased phospholipase A2 activity in the fetal membranes and placenta which is associated with labour is not due to increased phospholipase A2 gene expression, but that post translational control of phospholipase A2 activity may be mediated through changes in lipocortin I expression.

摘要

我们运用Northern印迹分析法，研究了人羊膜、绒毛膜蜕膜和胎盘组织中细胞型Ⅱ型磷脂酶A2以及脂皮质素（膜联蛋白）Ⅰ、Ⅱ和Ⅴ的表达情况。我们发现，分娩前后获取的组织中，磷脂酶A2或脂皮质素Ⅴ的表达并无差异。研究发现，随着分娩开始，羊膜和胎盘中脂皮质素Ⅰ的表达下降，而绒毛膜蜕膜中脂皮质素Ⅰ的表达增加，同时脂皮质素Ⅱ仅在羊膜中表达增加。这些结果支持了以下假说：胎膜和胎盘中与分娩相关的磷脂酶A2活性增加并非由于磷脂酶A2基因表达增加，而是磷脂酶A2活性的翻译后调控可能通过脂皮质素Ⅰ表达的变化介导。