Corchs J L, Corchs M J, Serrani R E
Cátedra de Fisiología Humana, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Argentina.
Rev Esp Fisiol. 1994 Mar;50(1):5-9.
Human fetal red cells show heterogeneity of 3H-ouabain binding sites. These cells were chosen as a model to look into unconjugated bilirubin effects on the primary active Na(+)-K+ transport mechanism. Evidences are presented suggesting that unconjugated bilirubin affects 3H-ouabain binding but not through a direct effect. This is supported by the fact that the "low affinity" subgroup sites of the last mentioned ligand persists after unconjugated bilirubin treatment of cells, whereas the "high-affinity" subgroup disappears.
人类胎儿红细胞显示出3H-哇巴因结合位点的异质性。选择这些细胞作为模型来研究未结合胆红素对原发性主动钠钾转运机制的影响。有证据表明，未结合胆红素会影响3H-哇巴因的结合，但并非通过直接作用。这一观点得到以下事实的支持：在用未结合胆红素处理细胞后，上述配体的“低亲和力”亚组位点仍然存在，而“高亲和力”亚组则消失了。
