用于诊断C型尼曼-匹克病的菲律宾菌素试验。
Filipin test for diagnosis of Niemann-Pick disease type C.
作者信息
Ledvinová J, Elleder M
机构信息
Laboratory of Protein Metabolism, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
出版信息
Sb Lek. 1993;94(2):137-43.
PMID:7992006
Abstract
The test is based on the reaction of unesterified cholesterol with fluorescent antibiotic filipin giving a strongly fluorescent, stable cholesterol-filipin complex suitable for in situ detection. The test is useful for the evaluation of impaired cholesterol esterification in cultured cells (fibroblasts or others) in Niemann-Pick disease type C.
摘要
该检测基于未酯化胆固醇与荧光抗生素制霉菌素的反应，生成一种强荧光、稳定的胆固醇 - 制霉菌素复合物，适用于原位检测。该检测对于评估尼曼 - 匹克病C型中培养细胞（成纤维细胞或其他细胞）中胆固醇酯化受损情况很有用。
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