Brinch L, Evensen S A, Egeland T, Solheim B G
Medisinsk avdeling A, Rikshospitalet, Oslo.
Tidsskr Nor Laegeforen. 1994 Aug 20;114(19):2242-3.
Infusion of haematopoietic stem cells, either autologous or allogeneic, allows treatment of malignant diseases with marrow ablative doses of cytostatics or whole body irradiation. Hospitalization and general anaesthesia is necessary for bone marrow harvesting, while the harvest of peripheral stem cells may be performed without hospitalization. Mobilization of haematopoietic stem cells from the bone marrow to peripheral blood, followed by cytapheresis and harvesting of the stem-cell containing fraction is a promising alternative to the harvest of marrow. We have tried this in one patient with advanced acute myeloid leukaemia and discuss our experience and that of others.
输注自体或异体造血干细胞，可使用大剂量细胞抑制剂或全身照射进行骨髓清除，从而治疗恶性疾病。采集骨髓需要住院并进行全身麻醉，而采集外周血干细胞则无需住院。将造血干细胞从骨髓动员至外周血，随后通过血细胞分离术采集含有干细胞的部分，这是一种有前景的骨髓采集替代方法。我们已在一名晚期急性髓系白血病患者身上尝试了这种方法，并讨论我们以及其他人的经验。
