Morimoto T, Sasa M, Monden Y, Sakai S
School of Medical Sciences, University of Tokushima.
Gan To Kagaku Ryoho. 1994 Dec;21(16):2821-4.
At age 35, the patient was diagnosed with left breast carcinoma (T4bN0M0, Stage IIIb) during her first pregnancy, and underwent mastectomy of the left breast and bilateral oophorectomy. Although CPA was administered as adjuvant chemotherapy after the operation, left pelvic pain developed about a year after the operation, and bone metastasis was detected from the imaging diagnosis. Then, the therapy was switched to UFT (600 mg/day) and tamoxifen (20 mg/day), which markedly relieved the pain along with bone scintiscan (NC) and simple X-P (NC). Five years have passed since the operation, and the progress is excellent. There is neither increase of pain nor adverse reactions to drugs. Furthermore, the patient received breast reconstruction operation at her strong insistence in the third year after operation, and has achieved a high quality of life (QOL).
35岁时，患者在首次怀孕期间被诊断为左乳腺癌（T4bN0M0，Ⅲb期），并接受了左乳乳房切除术和双侧卵巢切除术。尽管术后给予环磷酰胺作为辅助化疗，但术后约一年出现左盆腔疼痛，影像学诊断发现骨转移。然后，治疗改为优福定（600毫克/天）和他莫昔芬（20毫克/天），这显著缓解了疼痛，同时骨闪烁扫描（NC）和普通X光检查（NC）显示病情稳定。手术已过去五年，病情进展良好。既没有疼痛加剧，也没有药物不良反应。此外，患者在术后第三年强烈坚持下接受了乳房重建手术，并且生活质量（QOL）较高。
