中脑缝际刺激对主动回避反射维持的抑制作用。

Inhibitory effect of midbrain raphe stimulation on the maintenance of an active avoidance reflex.

作者信息

Kovács G L, Telegdy G

出版信息

Pharmacol Biochem Behav. 1976 Dec;5(6):709-11. doi: 10.1016/0091-3057(76)90317-8.

Abstract

Performance of an active avoidance (bench-jumping) reflex has been studied in rats during stimulation of the midbrain raphe nuclei. Raphe stimulation (10 cps, 0.2 msec, 2.5-5.0 V) inhibited the performance of the reflex. A serotonin receptor blocker (methysergide, 2.0 mg/kg IP) increased the reflex performance in non-stimulated animals and prevented the action of raphe stimulation. The data indicate that the cerebral serotoninergic system might have an inhibitory control over the performance of conditioned avoidance reflex.

摘要

在对大鼠中脑缝际核进行刺激期间，研究了主动回避（跳台）反射的表现。缝际核刺激（10次/秒，0.2毫秒，2.5 - 5.0伏）抑制了反射表现。一种血清素受体阻滞剂（麦角酰二乙胺，2.0毫克/千克腹腔注射）提高了未受刺激动物的反射表现，并阻止了缝际核刺激的作用。数据表明，大脑血清素能系统可能对条件回避反射的表现具有抑制性控制作用。