O'Dell K M
Institute of Genetics, University of Glasgow, Scotland.
Behav Genet. 1994 Jul;24(4):381-8. doi: 10.1007/BF01067539.
Flies carrying the inactive mutation of Drosophila melanogaster have only 15% wild-type titers of the putative neurotransmitter octopamine. With a view to discovering whether the inactive mutation impairs learning, I describe the effect of the inactive mutation on experience-dependent courtship modification (EDCM). Wild-type males rapidly condition to immature males and modify their behaviour toward subsequent target flies. The weaker EDCM phenotype of inactive males is similar to that of dunce males. Using time-sampling, habituation is most rapid for wild-type males and slowest for dunce males, with inactive males showing an intermediate phenotype. These results support the notion that octopamine plays a significant role in the manifestation of Drosophila learning behavior.
携带黑腹果蝇无活性突变的果蝇，其假定神经递质章鱼胺的滴度仅为野生型的15%。为了探究无活性突变是否会损害学习能力，我描述了无活性突变对经验依赖性求偶行为改变（EDCM）的影响。野生型雄性果蝇会迅速适应未成熟雄性果蝇，并改变它们对后续目标果蝇的行为。无活性雄性果蝇较弱的EDCM表型与迟钝雄性果蝇相似。通过时间抽样，野生型雄性果蝇的习惯化速度最快，迟钝雄性果蝇最慢，无活性雄性果蝇表现出中间表型。这些结果支持了章鱼胺在果蝇学习行为表现中起重要作用的观点。
