Fatigante L, Cartei F, Ducci F, Marini C, Prediletto R, Caciagli P, Laddaga M
Department of Radiology, University of Pisa, Italy.
Acta Oncol. 1994;33(7):807-11. doi: 10.3109/02841869409083952.
It has been reported that carbogen breathing yields a remarkable increase of radiosensitivity in murine tumour models. Hence, application of carbogen might be promising in radiotherapy of human tumours. We describe a method to increase arterial oxygenation and to ensure stability of O2 and CO2 during carbogen breathing in patients with malignant disease. We measured in 6 patients with histologically proven intracranial glioblastoma multiforme arterial blood gases, inspired and expired gas concentrations and vital signs either baseline and during carbogen breathing. The highest values of arterial oxygenation were achieved after 10 min of carbogen breathing and they remained stable up to 15 min. In none of our patients was N2 wash-out from the lungs completed in 15 min of carbogen breathing. In conclusion, carbogen breathing increased arterial oxygenation in patients with intracranial malignant diseases. The system used is reliable and of practical use. Monitoring of expired gas concentrations is highly recommended.
据报道，在小鼠肿瘤模型中，吸入卡波金可显著提高放射敏感性。因此，卡波金在人类肿瘤放疗中可能具有应用前景。我们描述了一种在恶性疾病患者吸入卡波金期间增加动脉氧合并确保氧气和二氧化碳稳定性的方法。我们对6例经组织学证实为多形性胶质母细胞瘤的患者在基线期和吸入卡波金期间测量了动脉血气、吸入和呼出气体浓度以及生命体征。吸入卡波金10分钟后达到最高动脉氧合值，且在15分钟内保持稳定。在我们的患者中，吸入卡波金15分钟内均未完成肺内氮气清除。总之，吸入卡波金可提高颅内恶性疾病患者的动脉氧合。所使用的系统可靠且实用。强烈建议监测呼出气体浓度。
