Tsokos G C
Department of Clinical Investigation, Walter Reed Army Medical Center, Washington, DC 20307-5001.
Curr Opin Rheumatol. 1994 Sep;6(5):461-7. doi: 10.1097/00002281-199409000-00002.
Patients with systemic lupus erythematosus display heterogeneous immune cell abnormalities that are now being understood in terms of the underlying molecular defects. The fraction of T cells that are involved in the pathogenesis of the disease is characterized in terms of T cell receptor expression, production of inappropriate quantities of lymphokines, and ability to provide help to B cells to produce autoantibodies. The function of antigen-presenting cells is studied in terms of presenting antigens and providing the proper costimulation to T cells. Better understanding of aberrant expression of adhesion molecules may set forward an abnormal tissue response and eventually the expression of clinical disease.
系统性红斑狼疮患者表现出异质性的免疫细胞异常，目前正根据潜在的分子缺陷来理解这些异常。参与该疾病发病机制的T细胞部分，是根据T细胞受体表达、产生不适量的淋巴因子以及为B细胞产生自身抗体提供帮助的能力来表征的。抗原呈递细胞的功能是根据呈递抗原以及为T细胞提供适当的共刺激来研究的。对黏附分子异常表达的更好理解可能会引发异常的组织反应，并最终导致临床疾病的表现。
