III型先天性红细胞生成异常性贫血中的血清胸苷激酶

Serum thymidine kinase in congenital dyserythropoietic anaemia type III.

作者信息

Sandström H, Wahlin A, Eriksson M, Bergström I

机构信息

Department of Family Medicine, University Hospital, Umeå, Sweden.

出版信息

Br J Haematol. 1994 Jul;87(3):653-4. doi: 10.1111/j.1365-2141.1994.tb08334.x.

DOI:10.1111/j.1365-2141.1994.tb08334.x

PMID:7993814

Abstract

Serum thymidine kinase (TK) was determined in a family with congenital dyserythropoietic anaemia type III (CDA, type III). 20 patients and 10 of their healthy siblings were investigated. Elevated TK was found in all 20 patients (median 56.2 U) but their healthy siblings had normal values (median 2.65 U). We suggest that determination of TK should be used for discrimination between healthy siblings and individuals affected by CDA type III when bone marrow examination is not suitable.

摘要

在一个患有III型先天性红细胞生成异常性贫血（CDA III型）的家族中测定了血清胸苷激酶（TK）。对20名患者及其10名健康的兄弟姐妹进行了调查。所有20名患者的TK均升高（中位数为56.2 U），但他们健康的兄弟姐妹的TK值正常（中位数为2.65 U）。我们建议，当骨髓检查不适用时，TK测定应用于区分健康的兄弟姐妹和受III型CDA影响的个体。