Sioufi A, Pommier F, Gauducheau N, Godbillon J, Choi L, John V
Laboratoires Ciba-Geigy, Biopharmaceutical Research Centre, Rueil-Malmaison, France.
Biopharm Drug Dispos. 1994 Aug;15(6):451-61. doi: 10.1002/bdd.2510150603.
Potential effects of the coadministration of single doses of aspirin (325 mg) and of benazepril hydrochloride (20 mg) on the pharmacokinetics and the metabolism of these two drugs were evaluated in 12 healthy subjects. Plasma concentration profiles of benazepril, its active metabolite benazeprilat, and total salicylic acid were determined together with urinary excretion of benazeprilat, salicylic acid, salicyluric acid, and salicylate glucuronides. Almost superimposable plasma profiles of benazepril, benazeprilat, and total salicylic acid were achieved with the drugs given alone and concomitantly. The coadministration of benazepril hydrochloride and aspirin did not modify the pharmacokinetics or the metabolism of the two drugs.
在12名健康受试者中评估了单剂量阿司匹林（325毫克）和盐酸贝那普利（20毫克）联合给药对这两种药物药代动力学和代谢的潜在影响。测定了贝那普利、其活性代谢产物贝那普利拉和总水杨酸的血浆浓度曲线，以及贝那普利拉、水杨酸、水杨尿酸和水杨酸葡萄糖醛酸苷的尿排泄情况。单独给药和联合给药时，贝那普利、贝那普利拉和总水杨酸的血浆曲线几乎重叠。盐酸贝那普利和阿司匹林联合给药未改变这两种药物的药代动力学或代谢。
