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15-脱氧精胍菌素可控制异基因骨髓移植后对环孢素和类固醇耐药的肠道急性移植物抗宿主病。

15-Deoxyspergualin controls cyclosporin- and steroid-resistant intestinal acute graft-versus-host disease after allogeneic bone marrow transplantation.

作者信息

Kasai M, Higa T, Naohara T, Masauzi N, Watanabe M, Matsuura A, Ohizumi H, Tanaka J, Morii K, Kiyama Y

机构信息

Sapporo Hokuyu Hospital, Artificial Organ and Transplantation Hospital, Japan.

出版信息

Bone Marrow Transplant. 1994 Aug;14(2):315-7.

PMID:7994248
Abstract

We report a case of cyclosporin- and methylprednisolone-resistant intestinal acute graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation which responded to a new immunosuppressant, 15-deoxyspergualin (DSG). Endoscopy showed lymphoid hyperplasia with CD3+, CD4+, CD8- lymphocyte infiltration into the submucosa of the jejunum and colon. DSG effectively suppressed this intestinal acute GVHD.

摘要

我们报告了1例异基因骨髓移植后对环孢素和甲基强的松龙耐药的肠道急性移植物抗宿主病（GVHD），其对新型免疫抑制剂15-脱氧精胍菌素（DSG）有反应。内镜检查显示空肠和结肠黏膜下层有淋巴细胞增生，伴有CD3 +、CD4 +、CD8 -淋巴细胞浸润。DSG有效抑制了这种肠道急性GVHD。

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Bone Marrow Transplant. 1994 Aug;14(2):315-7.
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