Tsubota K
Department of Ophthalmology, Tokyo Dental College, Chiba, Japan.
Scanning. 1994 Sep-Oct;16(5):295-9.
Specular microscopy is an important addition to the ophthalmologist's diagnostic armamentarium. Using this technique, it has been found that normal corneal epithelial cells are polygonal, with no abnormal specular reflex. There are no spindle-shaped, large or small cells, as may be observed in a variety of pathologic conditions. Spindle-shaped cells are characteristic of the wound-healing process with cell migration. Large cells were observed not only in wound healing, but also in aphakic diabetic patients, extended-wear soft contact lens wearers, and individuals with keratoconus. These changes may result from depressed mitosis or inhibited sloughing of superficial cells. Morphometric analysis adds a quantitative dimension to epithelial cell analysis.
镜面显微镜检查是眼科医生诊断工具的一项重要补充。通过这项技术发现，正常角膜上皮细胞呈多边形，无异常镜面反射。不存在纺锤形细胞、大细胞或小细胞，而这些细胞在多种病理状况下可能会被观察到。纺锤形细胞是细胞迁移的伤口愈合过程的特征。大细胞不仅在伤口愈合时可观察到，在无晶状体糖尿病患者、长期佩戴软性隐形眼镜者以及圆锥角膜患者中也可观察到。这些变化可能是由于有丝分裂受抑制或表层细胞脱落受抑制所致。形态计量分析为上皮细胞分析增添了定量维度。
