Ring H A, Bench C J, Trimble M R, Brooks D J, Frackowiak R S, Dolan R J
Institute of Neurology, London.
Br J Psychiatry. 1994 Sep;165(3):333-9. doi: 10.1192/bjp.165.3.333.
This study investigated biological correlates of depression in patients with idiopathic Parkinson's disease (PD). We tested the hypothesis that in patients with PD and depression, there was regional dysfunction involving brain areas previously implicated in functional imaging studies of patients with primary depression.
Using positron emission tomographic measurements of regional cerebral blood flow (rCBF), patterns of resting rCBF were measured in ten patients with PD and major depression, and ten patients with PD alone. The results were compared with findings from ten patients with primary depression and ten normal controls, scanned using identical methods as part of an earlier study. Groups were matched for age, sex and symptom severity.
Bilateral decreases in rCBF were observed in anteromedial regions of the medial frontal cortex and the cingulate cortex (Brodmann's areas (BA) 9 and 32) in the depressed PD group, compared with those with PD alone and compared with normal controls. This regional disturbance overlapped that observed in patients with primary depression.
The findings indicate that the medial prefrontal cortex is a common area of neural dysfunction in the manifestation of both primary depression and depression in PD.
本研究调查了特发性帕金森病（PD）患者抑郁症的生物学相关性。我们检验了以下假设：在患有PD和抑郁症的患者中，存在涉及先前在原发性抑郁症患者功能成像研究中所涉及脑区的局部功能障碍。
使用正电子发射断层扫描测量局部脑血流量（rCBF），对10例患有PD且伴有重度抑郁症的患者和10例仅患有PD的患者进行静息rCBF模式测量。将结果与10例原发性抑郁症患者和10例正常对照者的结果进行比较，这些对照者是作为一项早期研究的一部分，采用相同方法进行扫描的。各组在年龄、性别和症状严重程度方面进行了匹配。
与仅患有PD的患者以及正常对照者相比，抑郁的PD组在内侧额叶皮质和扣带回皮质（布罗德曼区（BA）9和32）的前内侧区域观察到rCBF双侧降低。这种局部紊乱与原发性抑郁症患者中观察到的情况重叠。
研究结果表明，内侧前额叶皮质是原发性抑郁症和PD患者抑郁症表现中神经功能障碍的共同区域。
