Tan C H, Chiang P C, Ng L L, Chee K T
Department of Pharmacology, Faculty of Medicine, Singapore.
Br J Psychiatry. 1994 Sep;165(3):381-3. doi: 10.1192/bjp.165.3.381.
The objective was to investigate the occurrence and characteristics of oculogyric spasm (OGS) in an Asian country.
All 2035 Asian (88% Chinese, 7% Malays and 5% Indonesians) psychiatric in-patients in the state psychiatric hospital in Singapore were surveyed for occurrence of oculogyric spasm (OGS) over a two-month period.
Thirty-four patients (1.7%) developed OGS (53% male and 47% female). All the 34 patients had been on maintenance antipsychotic drugs for more than five months. Eighteen patients had recurrent attacks. The mean chlorpromazine equivalent daily dose for those patients with recurrent OGS was 511 mg. This was significantly higher (P < 0.05) than the 277 mg daily dose received by those without recurrent OGS. Most (68%) of the attacks occurred between 1400-2000 h suggesting that OGS may have a diurnal variation.
OGS presenting as tardive dystonia may be due to a relative increase in cholinergic activity.
目的是调查亚洲某国家眼动危象（OGS）的发生率及特征。
对新加坡国立精神病院里的2035名亚洲精神科住院患者（88%为华人，7%为马来人，5%为印尼人）进行为期两个月的眼动危象（OGS）发生率调查。
34名患者（1.7%）出现眼动危象（OGS）（男性53%，女性47%）。所有34名患者均已服用维持性抗精神病药物超过五个月。18名患者有复发发作。复发性眼动危象（OGS）患者的氯丙嗪等效日剂量平均为511毫克。这显著高于（P<0.05）无复发性眼动危象（OGS）患者所接受的277毫克日剂量。大多数（68%）发作发生在14:00 - 20:00之间，提示眼动危象（OGS）可能有昼夜变化。
表现为迟发性肌张力障碍的眼动危象（OGS）可能是由于胆碱能活性相对增加所致。
