Shiota G, Okano J, Umeki K, Kawasaki H, Kawamoto T, Nakamura T
Second Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.
Res Commun Mol Pathol Pharmacol. 1994 Aug;85(2):157-62.
Serum hepatocyte growth factor (HGF) levels in patients with acute hepatic failure has been reported to increase. However, possible mechanisms responsible for HGF elevation in this syndrome remains to be determined. To explore the possible mechanisms, we measured serum HGF in patients with acute hepatic failure and self-limited acute hepatitis, using an immunoradiometric assay. Serum HGF levels in acute hepatic failure were 36-fold higher compared with those in acute hepatitis. Serum HGF values in acute hepatitis were significantly correlated with serum bilirubin and gamma-GTP levels, whereas those in acute hepatic failure were not. These clinical findings suggest that serum HGF levels in acute hepatic failure may be regulated by different mechanisms from those in self-limited acute hepatitis.
据报道，急性肝衰竭患者血清肝细胞生长因子（HGF）水平会升高。然而，该综合征中HGF升高的可能机制仍有待确定。为了探究可能的机制，我们采用免疫放射分析方法测定了急性肝衰竭患者和自限性急性肝炎患者的血清HGF。急性肝衰竭患者的血清HGF水平比急性肝炎患者高36倍。急性肝炎患者的血清HGF值与血清胆红素和γ-谷氨酰转肽酶水平显著相关，而急性肝衰竭患者的血清HGF值则不然。这些临床发现表明，急性肝衰竭患者血清HGF水平的调节机制可能与自限性急性肝炎不同。
