暴露于抗癌药物阿霉素的K562细胞中膜流动性的改变。
Alterations of membrane fluidity in K562 cells exposed to the anticancer drug adriamycin.
作者信息
Marutaka M, Iwagaki H, Suguri T, Tanaka N, Orita K
机构信息
First Department of Surgery, Okayama University Medical School, Japan.
出版信息
Res Commun Mol Pathol Pharmacol. 1994 Aug;85(2):163-70.
The incubation of K562 cells with adriamycin resulted in a decrease in cell membrane fluidity as measured by electron spin resonance using the paramagnetic probe 5-doxylstearic acid. Coincidently, the antiproliferative effect of adriamycin was progressively inhibited as the concentration of adriamycin was increased. The results indicate that adriamycin induces changes in the plasma membrane of K562 cells after exposure to a low level of this agent.
用阿霉素孵育K562细胞，通过电子自旋共振使用顺磁探针5-硬脂酰氧基-二苯甲酰基甲基自由基来测量，结果显示细胞膜流动性降低。巧合的是，随着阿霉素浓度的增加，其抗增殖作用逐渐受到抑制。结果表明，在低水平接触该药物后，阿霉素会诱导K562细胞的质膜发生变化。
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