Neurobiology of piperidine: its relevance to CNS function.

Piperidine is a normal constituent in mammalian brain, affects synaptic mechanism in the CNS, and influences neural mechanisms governing regulation of emotional behavior, sleeping, and extrapyramidal function. In addition, there are enzyme systems within the brain that synthesize and metabolize piperidine, and uptake and storage mechanisms for piperidine are found in the nerve endings. In conclusions, piperidine seems to be intimately connected with the neuronal function of the brain.