Capron M, Desreumaux P, Gouni A S, Lamkhioued B, Capron A
Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, Lille, France.
C R Seances Soc Biol Fil. 1994;188(1):39-46.
The demonstration that human eosinophils could express various membrane receptors (for IgG, IgE, IgA; for complement; for cytokines; for chemotactic factors), for adhesion molecules (VLA4, LFAI, OKM1), as well as CD4 and class II MHC, has allowed to reconsider the role of eosinophils in immune response. Indeed, eosinophils can function as antigen presenting cells and can be infected by HIV. Studies on eosinophil mediators have revealed that eosinophils are not only the source of cytotoxic and proinflammatory mediators but can also release various cytokines and growth factors, including their own factors of differentiation (IL-3, GM-CSF and IL-5). The recent observation that eosinophils expressed IgE binding molecules belonging to different gene superfamilies (CD23, Mac2/epsilon BP and FceRI), as well as two different IgA receptors (Fc alpha R, and secretory component binding site), participating both in antiparasite immune defence and in inflammatory processes, reinforces the concept of the functional duality of eosinophils, specially in tissues.
人类嗜酸性粒细胞能够表达多种膜受体（针对IgG、IgE、IgA；针对补体；针对细胞因子；针对趋化因子）、黏附分子（VLA4、LFAI、OKM1）以及CD4和II类主要组织相容性复合体，这一发现促使人们重新审视嗜酸性粒细胞在免疫反应中的作用。事实上，嗜酸性粒细胞可作为抗原呈递细胞，并且能够被HIV感染。对嗜酸性粒细胞介质的研究表明，嗜酸性粒细胞不仅是细胞毒性和促炎介质的来源，还能释放多种细胞因子和生长因子，包括其自身的分化因子（IL-3、GM-CSF和IL-5）。最近的观察发现，嗜酸性粒细胞表达属于不同基因超家族的IgE结合分子（CD23、Mac2/εBP和FceRI），以及两种不同的IgA受体（FcαR和分泌成分结合位点），它们既参与抗寄生虫免疫防御，也参与炎症过程，这进一步强化了嗜酸性粒细胞功能双重性的概念，尤其是在组织中。
