Palatini P, Graniero G R, Mormino P, Nicolosi L, Mos L, Visentin P, Pessina A C
Clinica Medica 1, University of Padua, Italy.
Circulation. 1994 Dec;90(6):2870-6. doi: 10.1161/01.cir.90.6.2870.
This study was undertaken to assess whether ambulatory blood pressure (BP) in a population of stage I hypertensive individuals was lower in the subjects performing regular exercise training.
The study was carried out in 796 young hypertensive patients (592 men) who had never been treated who took part in the HARVEST trial. The diagnosis of stage I hypertension was made on the basis of six office BP measurements. Subjects underwent noninvasive 24-hour ambulatory BP monitoring, 24-hour urine collection for catecholamine assessment, and echocardiography (n = 457). They were classified as exercisers if they reported at least one session of aerobic sports per week and as nonexercisers if they did not engage regularly in sports activities. Age (P < .0001), body mass index (P = .002), 24-hour heart rate (P < .0001), alcohol intake (P = .02), smoking (P = .02), and norepinephrine output (P = .04) were lower in the active (n = 153) than the inactive (n = 439) men. Physically active men exhibited a lower 24-hour and daytime diastolic BP than the inactive men, while there were no group differences in office BP or in nighttime diastolic BP and in ambulatory systolic BP. The between-group ambulatory diastolic BP difference remained statistically significant after adjustment for age, body mass index, alcohol intake, and smoking (P < .0001). Of the nonexercisers, 46.2% were confirmed hypertensives, compared with only 26.8% of the exercisers (P < .0001), on the basis of daytime diastolic BP. Echocardiographic left ventricular dimensional and functional indexes were similar in the two groups of men. Similar findings were shown by the 16 women who engaged in aerobic sports.
These data suggest that participation in aerobic sports may attenuate the risk of hypertension in young subjects whose office BP is in the stage I hypertensive range at office measurement.
本研究旨在评估在未经治疗的I期高血压人群中，进行规律运动训练的受试者的动态血压是否更低。
该研究在796例从未接受过治疗且参与了HARVEST试验的年轻高血压患者（592例男性）中开展。I期高血压的诊断基于6次诊室血压测量。受试者接受了无创24小时动态血压监测、24小时尿儿茶酚胺评估及超声心动图检查（n = 457）。若受试者报告每周至少进行一次有氧运动，则被分类为运动者；若未定期参与体育活动，则被分类为非运动者。活跃组（n = 153）男性的年龄（P <.0001）、体重指数（P =.002）、24小时心率（P <.0001）、酒精摄入量（P =.02）、吸烟情况（P =.02）及去甲肾上腺素排出量（P =.04）均低于不活跃组（n = 439）男性。与不活跃男性相比，体力活跃的男性24小时及日间舒张压更低，而诊室血压、夜间舒张压及动态收缩压在两组间无差异。在对年龄、体重指数、酒精摄入量及吸烟情况进行校正后，两组间的动态舒张压差异仍具有统计学意义（P <.0001）。基于日间舒张压，非运动者中有46.2%被确诊为高血压患者，而运动者中仅为26.8%（P <.0001）。两组男性的超声心动图左心室维度及功能指标相似。16例进行有氧运动的女性也显示出类似结果。
这些数据表明，对于诊室血压处于I期高血压范围的年轻受试者，参与有氧运动可能会降低高血压风险。
