Nagayama S, Takashima H, Matsui M, Kuroda Y, Kato A
Department of Internal Medicine, Saga Medical School.
Rinsho Shinkeigaku. 1994 Aug;34(8):845-7.
We report a 63-year-old man presenting with dementia and cerebellar ataxia associated with multiple iron deposits in the brain on MRI. Numerous small lesions of low-intensity on both T1- and T2-weighted images were found in the parenchyma and surface of the cerebrum, cerebellum and brain stem. The number and size of lesions were increased on MRI with the method of gradient recalled acquisition in the steady state (GRASS), indicating that they were composed of iron. The similar lesions were not found in any organs on the abdominal GRASS-MRI. Any abnormalities were also not found in the cerebral angiography. Meanwhile, the protein and IgG levels and activated CD4-cells were increased in the cerebrospinal fluid, indicating the involvement of chronic inflammation in the iron deposits in this case.
我们报告了一名63岁男性，其患有痴呆症和小脑共济失调，MRI显示脑部有多处铁沉积。在大脑、小脑和脑干的实质及表面，T1加权和T2加权图像上均发现了许多低强度的小病灶。采用稳态梯度回波采集（GRASS）方法的MRI显示病灶的数量和大小增加，表明它们由铁组成。腹部GRASS-MRI未在任何器官中发现类似病灶。脑血管造影也未发现任何异常。同时，脑脊液中的蛋白质和IgG水平以及活化的CD4细胞增加，表明该病例中铁沉积涉及慢性炎症。
