Krivosic-Horber R, Adnet P
Département d'Anesthésie réanimation chirurgicale, Centre Hospitalier Régional Universitaire, Lille.
Chirurgie. 1993;119(1-2):55-8.
A rare complication of general anesthesia, malignant hyperthermia is nonetheless very topical because it causes the death of young, healthy subjects who most often undergo surgery with no vital risk. Screening, an essential means of achieving riskless anesthesia, is based on testing on fresh biopsy specimens of muscle. The current state of knowledge, especially the progress made in genetics, will be commented.
恶性高热是全身麻醉的一种罕见并发症,但它备受关注,因为它会导致年轻健康的受试者死亡,而这些受试者通常是在没有生命危险的情况下接受手术的。筛查是实现无风险麻醉的重要手段,基于对新鲜肌肉活检标本的检测。本文将对当前的知识状况,尤其是遗传学方面取得的进展进行评述。