Rosete Rossetti R, Alvarado García A, Bustos López H H, Barrón Vallejo J, Sinibaldi Gómez J
R4 Biología de la Reproducción Humana, Instituto Nacional de Perinatología, Méx. D.F.
Ginecol Obstet Mex. 1994 Oct;62:308-11.
This study evaluates the effect of gonadotropin releasing hormone (GnRH) administration on serum levels of FSH and LH. Also, relate those results with histopathologic findings of testicular biopsies. This was a prospective, clinical trial with a control group. It was done at Department of Reproductive Biology "20 de Noviembre" Hospital, ISSSTE, México City. Fifteen azoospermic, normogonadotropic patients without testicular atrophy and ten normal men use as control group. A GnRH challenge test was made in both groups, two days after we perform a testicular biopsy in patients with azoospermia. There was no significant difference in serum LH concentrations between the two groups, neither before or after GnRH challenge test. There was a statistical difference between serum FSH values of azoospermic patients, than those of control group, the former with higher values than those of the latter. As worst testicular damage was, we found also a higher FSH value on the GnRH challenge test. The GnRH challenge test perform in azoospermic, normogonadotropic patients is very helpful to detect those patients with gonadal damage. As higher the FSH values were, we found that an abnormal testicular biopsy was also more common.
本研究评估促性腺激素释放激素（GnRH）给药对血清卵泡刺激素（FSH）和黄体生成素（LH）水平的影响。此外，将这些结果与睾丸活检的组织病理学发现相关联。这是一项设有对照组的前瞻性临床试验。研究在墨西哥城ISSSTE的“11月20日”医院生殖生物学部进行。15名无精子症、性腺功能正常且无睾丸萎缩的患者以及10名正常男性作为对照组。在无精子症患者进行睾丸活检两天后，两组均进行了GnRH激发试验。两组之间血清LH浓度在GnRH激发试验前后均无显著差异。无精子症患者的血清FSH值与对照组相比存在统计学差异，前者的值高于后者。睾丸损伤越严重，在GnRH激发试验中发现的FSH值越高。在无精子症、性腺功能正常的患者中进行GnRH激发试验对检测性腺损伤患者非常有帮助。FSH值越高，我们发现异常睾丸活检也越常见。
