Bleich A, Attias J, Zinger Y
Dept. of Psychiatry, Tel Aviv-Souraski Medical Center.
Harefuah. 1994 Nov 15;127(10):364-8, 432.
To evaluate certain aspects of cognitive processing in posttraumatic stress disorder (PTSD), brain event-related potentials, primarily P300, to traumatic stimuli were recorded. 20 Israeli veterans with PTSD of combat origin and matched controls were studied. In a modification of the oddball paradigm, subjects were asked to react to target pictures of traumatic combat-related subjects while ignoring non-target pictures of irrelevant subjects. PTSD patients reacted with an accentuated P300 and prolonged reaction times to the traumatic pictures. In addition, P300 and reaction times to the target pictures were prolonged in PTSD patients as compared to controls. Event-related potentials (P300) to traumatic stimuli can serve as an objective and accurate brain parameter for characterization and diagnosis of PTSD. In addition, it contributes to understanding the pathogenesis of PTSD as a specific impairment in information processing.
为评估创伤后应激障碍（PTSD）中认知加工的某些方面，记录了大脑对创伤性刺激的事件相关电位，主要是P300。对20名具有战斗起源PTSD的以色列退伍军人及匹配的对照组进行了研究。在对Oddball范式的一种改进中，要求受试者对与创伤性战斗相关主题的目标图片做出反应，同时忽略无关主题的非目标图片。PTSD患者对创伤性图片的反应表现为P300增强且反应时间延长。此外，与对照组相比，PTSD患者对目标图片的P300和反应时间也延长。对创伤性刺激的事件相关电位（P300）可作为表征和诊断PTSD的客观准确的脑参数。此外，它有助于理解PTSD作为信息加工中的一种特定损伤的发病机制。
