Bhatt R, Pandit D, Deodhar L, Bhise R, Chatterjee D K
Dept of Microbiology, LTM Medical College, Sion, Bombay, Maharashtra.
J Postgrad Med. 1993 Oct-Dec;39(4):187-9.
Pathogenicity of 19 isolates of Trichomonas vaginalis obtained from vaginal specimens were studied in the murine model by intraperitoneal inoculation. Sixteen isolates were recovered from the females with various clinical conditions and 3 isolates were from normal healthy females. Pathogenicity level of these isolates were studied by inoculating 5 mice per isolate through intraperitoneal route and the animals were sacrificed on the 10th day post-inoculation. In general, all the isolates recovered produced infection in mice. On comparison with the reference strain obtained from Hoechst India Ltd., seven isolates recovered from symptomatic cases and one strain from healthy females produced severe infection in mice. Though variation in the pathogenicity level was observed among the isolates, a definite correlation between the clinical picture in the natural host and pathogenicity in mice was not observed.
通过腹腔接种，在小鼠模型中研究了从阴道标本中分离出的19株阴道毛滴虫的致病性。16株分离株来自患有各种临床病症的女性，3株分离株来自正常健康女性。通过经腹腔途径为每个分离株接种5只小鼠来研究这些分离株的致病水平，并在接种后第10天处死动物。总体而言，所有回收的分离株均在小鼠中产生感染。与从印度赫斯特有限公司获得的参考菌株相比，从有症状病例中回收的7株分离株和从健康女性中获得的1株菌株在小鼠中产生了严重感染。尽管在分离株之间观察到致病水平存在差异，但未观察到自然宿主中的临床症状与小鼠致病性之间存在明确的相关性。
