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一系列氮杂查耳酮衍生物对大鼠多形核白细胞髓过氧化物酶释放的抑制作用。

Inhibition of myeloperoxidase release from rat polymorphonuclear leukocytes by a series of azachalcone derivatives.

作者信息

Edwards M L, Stemerick D M, Sabol J S, Diekema K A, Dinerstein R J

机构信息

Marion Merrell Dow Research Institute, Cincinnati, Ohio 45215.

出版信息

J Med Chem. 1994 Dec 9;37(25):4357-62. doi: 10.1021/jm00051a013.

DOI:10.1021/jm00051a013
PMID:7996547
Abstract

A series of azachalcones was evaluated for ability to affect secretion of myeloperoxidase by rat polymorphonuclear leukocytes stimulated by fMLP. The compounds were found to interfere with cellular uptake of extracellular calcium. Structure-activity relationships are discussed.

摘要

对一系列氮杂查耳酮进行了评估，以确定其对受N-甲酰甲硫氨酰亮氨酰苯丙氨酸（fMLP）刺激的大鼠多形核白细胞分泌髓过氧化物酶能力的影响。发现这些化合物会干扰细胞对细胞外钙的摄取。并讨论了构效关系。

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Photodimerizations of hydroxy- and benzoylated 4-azachalcones and quantum chemical investigation of the reactions.羟基和苯甲酰化 4-氮杂查耳酮的光二聚反应及反应的量子化学研究。
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