Khand F D, Ansari A F, Khand T U, Memon J M
Department of Pharmacy, University of Sindh, Jamshoro.
J Pak Med Assoc. 1994 Aug;44(8):179-81.
The serum and 24 hour urinary excretion levels of various lithogenic and inhibitory substances were assessed in 24 male patients with calcium stone and no previous history of urolithiasis and in 19 age-matched controls. Two groups did not differ significantly (P < 0.01) except in the excretions of sodium, citric acid (being higher in normals) and inorganic phosphate (being higher in patients). Fifty percent patients had hyperphosphaturia, 29.2% hypocitraturia, 20.8% hyperoxaluria and 16.7% hypercalciuria. The present data suggests that hypocitraturia in association with phosphaturia might be one of the main risk factors responsible for calcium urolithiasis in this area.
对24例患有钙结石且既往无尿石症病史的男性患者以及19例年龄匹配的对照组进行了各种致石和抑制物质的血清及24小时尿排泄水平评估。除了钠、柠檬酸（正常人中较高）和无机磷酸盐（患者中较高）的排泄量外，两组之间无显著差异（P<0.01）。50%的患者有高磷尿症，29.2%有低枸橼酸尿症，20.8%有高草酸尿症，16.7%有高钙尿症。目前的数据表明，低枸橼酸尿症与磷尿症相关可能是该地区钙尿石症的主要危险因素之一。
