Kemp G J
MRC Biochemical and Clinical Magnetic Resonance Unit, John Radcliffe Hospital, Oxford, U.K.
J Theor Biol. 1994 Oct 7;170(3):239-46. doi: 10.1006/jtbi.1994.1184.
In skeletal muscle, creatine kinase imposes constraints on the concentrations of phosphocreatine, creatine, ATP and ADP, which complicate our understanding of the regulation of mitochondrial ATP synthesis, because correlations between oxidation rate (Q) and metabolite concentrations cannot prove causal relations. Two kinds of theory of mitochondrial control in vivo have evolved, based on (i) the hyperbolic relationship between Q and cytosolic [ADP] and (ii) linear correlations between Q and, for example, free energy of ATP hydrolysis. This paper examines some relationships between these theories in order to show (i) to what extent they may be regarded as different expressions of the same metabolic mechanisms, (ii) how they can be understood in terms of general principles of feedback control, and (iii) how they explain relationships between mitochondrial function and resting metabolite concentrations.
在骨骼肌中，肌酸激酶对磷酸肌酸、肌酸、三磷酸腺苷（ATP）和二磷酸腺苷（ADP）的浓度施加限制，这使得我们对线粒体ATP合成调节的理解变得复杂，因为氧化速率（Q）与代谢物浓度之间的相关性无法证明因果关系。基于（i）Q与胞质[ADP]之间的双曲线关系以及（ii）Q与例如ATP水解自由能之间的线性相关性，体内线粒体控制的两种理论已经发展起来。本文研究了这些理论之间的一些关系，以表明（i）它们在多大程度上可被视为相同代谢机制的不同表达，（ii）如何根据反馈控制的一般原则来理解它们，以及（iii）它们如何解释线粒体功能与静息代谢物浓度之间的关系。
