Thompson C H, Kemp G J, Sanderson A L, Dixon R M, Styles P, Taylor D J, Radda G K
MRC Biochemical and Clinical Magnetic Resonance Unit, John Radcliffe Hospital, Headington, Oxfor, United Kingdom.
Br J Sports Med. 1996 Sep;30(3):222-5. doi: 10.1136/bjsm.30.3.222.
To examine the effect of a relatively low dose of creatine on skeletal muscle metabolism and oxygen supply in a group of training athletes.
31P magnetic resonance and near-infrared spectroscopy were used to study calf muscle metabolism in a group of 10 female members of a university swimming team. Studies were performed before and after a six week period of training during which they took either 2 g creatine daily or placebo. Calf muscle metabolism and creatine/choline ratios were studied in resting muscle, during plantar flexion exercise (10-15 min), and during recovery from exercise.
There was no effect of creatine on metabolite ratios at rest or on metabolism during exercise and recovery from exercise. Muscle oxygen supply and exercise performance were not improved by creatine if compared to placebo treated subjects.
Oral creatine supplementation at 2 g daily has no effect on muscle creatine concentration, muscle oxygen supply or muscle aerobic or anaerobic metabolism during endurance exercise.
研究相对低剂量的肌酸对一组训练运动员骨骼肌代谢和氧气供应的影响。
采用31P磁共振和近红外光谱法，对一所大学游泳队的10名女性队员的小腿肌肉代谢进行研究。在为期六周的训练前后进行研究，在此期间，她们每天服用2克肌酸或安慰剂。在静息肌肉、跖屈运动（10 - 15分钟）期间以及运动恢复期间，研究小腿肌肉代谢和肌酸/胆碱比率。
肌酸对静息代谢物比率、运动期间以及运动恢复期间的代谢均无影响。与接受安慰剂治疗的受试者相比，肌酸并未改善肌肉氧气供应和运动表现。
每天口服2克肌酸对耐力运动期间的肌肉肌酸浓度、肌肉氧气供应或肌肉有氧或无氧代谢均无影响。
