Riggs J E
Department of Neurology, Medicine and Community Medicine, West Virginia University School of Medicine, Morgantown 26506.
J Theor Biol. 1994 Oct 21;170(4):331-8. doi: 10.1006/jtbi.1994.1195.
Aging-related carcinogenesis has been attributed to inherent genetic instability, which manifests in a multistep fashion by activation of oncogenes and inactivation of tumor suppressor genes. Malignant brain tumor cells display multiple-characteristic acquired genetic abnormalities in oncogenes and tumor suppressor genes. Age-specific malignant brain tumor mortality rates in the United States from 1962 to 1988 were interpreted by longitudinal Gompertzian analysis. Utilizing a thermodynamic perspective of the Strehler-Mildvan modification of the Gompertz relationship between mortality and aging, a measure of the rate of increase in informational entropy for those genetic factors involved in the carcinogenesis of malignant brain tumor was determined. Aging-related carcinogenesis can be viewed as a natural consequence of increasing informational entropy of the genome.
与衰老相关的致癌作用被归因于内在的基因不稳定，其通过癌基因的激活和肿瘤抑制基因的失活以多步骤方式表现出来。恶性脑肿瘤细胞在癌基因和肿瘤抑制基因中显示出多种获得性基因异常。1962年至1988年美国特定年龄的恶性脑肿瘤死亡率通过纵向冈珀茨分析进行了解释。利用斯特勒-米尔德万对死亡率与衰老之间冈珀茨关系的修正的热力学观点，确定了参与恶性脑肿瘤致癌作用的那些遗传因素的信息熵增加率的一种度量。与衰老相关的致癌作用可被视为基因组信息熵增加的自然结果。
