Lin C P, Weaver Y K, Birngruber R, Fujimoto J G, Puliafito C A
Laser Research Laboratory, New England Eye Center, Tufts University School of Medicine, Boston, Massachusetts 02111.
Lasers Surg Med. 1994;15(1):44-53. doi: 10.1002/lsm.1900150107.
We investigated the use of picosecond Nd:YAG laser pulses for intraocular microsurgery. With a pulse duration of 100 picoseconds, only 70 microJ of pulse energy is required to consistently produce optical breakdown in the deep vitreous. This pulse energy is nearly two orders of magnitude less than the typical pulse energies used in conventional (nanosecond) photodisruptors. The reduced pulse energy results in a smaller zone of tissue damage, an important consideration when operating close to the retina or other sensitive ocular structures. Efficient cutting action is achieved by applying multiple pulses at a moderately high repetition rate of 50-200 Hz. An in vitro model was developed to assess axial confinement of picosecond photodisruption. In vivo vitreous membrane surgery was performed in experimental rabbit eyes to demonstrate a potential clinical application of picosecond laser-induced optical breakdown.
钇铝石榴石激光脉冲在眼内显微手术中的应用。脉冲持续时间为100皮秒时，仅需70微焦的脉冲能量就能在深层玻璃体中持续产生光击穿。该脉冲能量比传统（纳秒）光破碎器中使用的典型脉冲能量低近两个数量级。脉冲能量的降低导致组织损伤区域更小，这在靠近视网膜或其他敏感眼部结构进行手术时是一个重要的考虑因素。通过以50 - 200赫兹的适度高重复率施加多个脉冲，可实现高效切割作用。开发了一个体外模型来评估皮秒光破碎的轴向限制。在实验兔眼中进行了体内玻璃体膜手术，以证明皮秒激光诱导光击穿的潜在临床应用。
