神经移植、营养因子与帕金森病

Neural transplantation, trophic factors and Parkinson's disease.

作者信息

Kupsch A, Oertel W H

机构信息

Klinikum Grosshadern, Neurological Unit, Ludwig-Maximilians-University, München, FRG.

出版信息

Life Sci. 1994;55(25-26):2083-95. doi: 10.1016/0024-3205(94)00389-0.

DOI:10.1016/0024-3205(94)00389-0

PMID:7997067

Abstract

Part 1 of this update on new restorative therapeutic strategies against Parkinsons's disease focuses on transplantation of dopamine-secreting tissue. Special emphasis is put on clinical trials with fetal mesencephalic cells. Problems and potential alternative approaches are discussed. Part 2 emphasizes progress in the related field of neurotrophic factors for dopaminergic midbrain neurons.

摘要

关于帕金森病新型恢复性治疗策略的这一更新内容的第一部分聚焦于分泌多巴胺组织的移植。特别强调了胎儿中脑细胞的临床试验。讨论了相关问题及潜在的替代方法。第二部分着重介绍了多巴胺能中脑神经元神经营养因子相关领域的进展。