Sarac R, Sedlak-Vadoc V
Institut medicinskih sluzbi, Medicinski fakultet, Novi Sad.
Med Pregl. 1993;46(11-12):449-53.
Clearance of the endogenous creatinine is a simple method for application, it is relatively cheap and applicable in almost all surroundings, but it is not reliable enough when the obtained results are concerned. This report shows the results of determining this clearance in comparison with radiosotope clearance 51 cr-EDTA, referent for clinical research, in 52 outpatients with primary and secondary kidney diseases. It was found that values of clearance of the endogene creatinine (Clkr) are significantly lower than the clearance 51 Cr-EDTA (ClEDTA) (t = 2.391, p < 0.01) and that the correlation between the two method is poor (r = 0.688). The source of mistakes should be looked for (and strictly controlled) when gathering diuresis, because the biochemical method of creatnine concentration determination of the biologic material itself is reliable enough.
内源性肌酐清除率是一种应用简便的方法，相对便宜且几乎适用于所有环境，但就所得结果而言，其可靠性不足。本报告展示了在52例原发性和继发性肾病门诊患者中，将该清除率测定结果与临床研究参考的放射性同位素51铬-乙二胺四乙酸（51Cr-EDTA）清除率进行比较的结果。研究发现，内源性肌酐清除率（Clkr）的值显著低于51Cr-EDTA清除率（ClEDTA）（t = 2.391，p < 0.01），且两种方法之间的相关性较差（r = 0.688）。在收集尿液时应寻找（并严格控制）错误来源，因为生物材料中肌酐浓度的生化测定方法本身足够可靠。
