Cvejanov M, Pejakov L, Marinković S, Peković V, Sterio M, Dobanovacki D, Tatić M
Institut za zdravstvenu zastitu dece i omladine, Medicinski fakultet, Novi Sad.
Med Pregl. 1993;46(9-10):353-6.
For a long period of time propofol has been in use for total intravenous anesthesia in adults. In our literature there are no data on the use of propofol in pediatric anesthesia. The aim of the study was to compare effects of propofol for the induction of anesthesia, maintenance and recovery after anesthesia, with barbiturate, that is, inhalation anesthesia during spontaneous breathing. 50 children underwent propofol anesthesia. A control group comprised 50 children who underwent thiopentone and halothane anesthesia. The average propofol dose was 2.38 mg/kg/tt. Monitoring of cardiovascular parameters revealed statistically significant variations in systolic and diastolic pressure in both groups, but a more significant decrease was recorded in the propofol group. The decrease, recorded only during the initiation of anesthesia, stabilized afterwards. Side effects (pain during the initiation, apnea, spontaneous movements) were present in the propofol anesthesia, while in the halothane group they were reduced. In the propofol group period of recovery was short, indicating advantages of this anesthetic in day care centers.
长期以来，丙泊酚一直用于成人的全静脉麻醉。在我们的文献中，没有关于丙泊酚用于小儿麻醉的资料。本研究的目的是比较丙泊酚与巴比妥类药物（即自主呼吸时的吸入麻醉）在麻醉诱导、维持及麻醉后恢复方面的效果。50名儿童接受了丙泊酚麻醉。一个对照组由50名接受硫喷妥钠和氟烷麻醉的儿童组成。丙泊酚的平均剂量为2.38毫克/千克/次。心血管参数监测显示，两组的收缩压和舒张压均有统计学上的显著变化，但丙泊酚组的下降更为显著。这种下降仅在麻醉开始时出现，随后趋于稳定。丙泊酚麻醉存在副作用（开始时疼痛、呼吸暂停、自主运动），而氟烷组的副作用则较少。丙泊酚组的恢复时间较短，表明这种麻醉剂在日间护理中心具有优势。
