Kemp E, Hellerström C
Nefrologisk afdeling, Odense Universitetshospital.
Nord Med. 1994;109(12):335-7.
The ultimate purpose of research in xenografting (cross-species transplantation) is successful transplantation of tissue and organs from animals to human patients. Success in the clinical application of xenografting would mean an end to the shortage of donor organs. Xenografts are classified as concordant or discordant, depending on rejection factors and histology. Several clinical attempts have been made since 1963, but success has been limited. However, great progress has been made in laboratory attempts; and the procedures should now be given clinical trials. This success has been due to the efficacy of many of the newly developed immunosuppressive drugs. Discordant xenografting is still problematic, and in this type of transplantation the most promising approach would seem to be with isolated cells or cell clusters.
异种移植（跨物种移植）研究的最终目的是将动物的组织和器官成功移植到人类患者体内。异种移植临床应用的成功将意味着供体器官短缺问题的终结。根据排斥因素和组织学，异种移植可分为协调性或非协调性。自1963年以来已经进行了几次临床尝试，但成功有限。然而，实验室尝试已取得了很大进展；现在应该对这些程序进行临床试验。这一成功得益于许多新开发的免疫抑制药物的功效。非协调性异种移植仍然存在问题，在这类移植中，最有前景的方法似乎是使用分离的细胞或细胞团。
