Venz S, Cordes M, Straub H B, Hierholzer J, Schröder R, Richter W, Schmitz B, Meencke H, Felix R
Strahlenklinik und Poliklinik, des Universitätsklinikums Rudolf, Virchow/W, FU Berlin, FRG.
Nuklearmedizin. 1994 Oct;33(5):189-93.
SPECT with the benzodiazepine receptor antagonist 123I-Iomazenil was performed in 33 patients with intractable partial seizures for pre-operative evaluation. The results combined with MRI and 99mTc-HMPAO-SPECT findings were compared with the video-assisted EEG monitoring ("gold standard") which localised the focus in 25 patients. 11 patients underwent surgical resection of the epileptogenic area and became seizure-free for a period up to 13 months. The Iomazenil SPECT had a significantly higher sensitivity compared to 99mTc-HMPAO in the visualization of an epileptogenic area and should be regularly used in the diagnostic of medically intractable partial seizures.
对33例难治性部分性癫痫患者进行了使用苯二氮䓬受体拮抗剂123I-碘美西尼的单光子发射计算机断层扫描（SPECT）以进行术前评估。将其结果与磁共振成像（MRI）及99m锝-六甲基丙烯胺肟单光子发射计算机断层扫描（99mTc-HMPAO-SPECT）结果相结合，并与25例患者癫痫病灶定位的视频辅助脑电图监测（“金标准”）进行比较。11例患者接受了癫痫病灶区域的手术切除，术后癫痫发作停止长达13个月。在癫痫病灶区域的可视化方面，碘美西尼SPECT的敏感性显著高于99mTc-HMPAO，应常规用于药物难治性部分性癫痫的诊断。
