自由基诱导的双碱基损伤。
Free radical-induced double base lesions.
作者信息
Box H C, Freund H G, Budzinski E E, Wallace J C, Maccubbin A E
机构信息
Biophysics Department, Roswell Park Cancer Institute, Buffalo, New York 14263.
出版信息
Radiat Res. 1995 Jan;141(1):91-4.
PMID:7997520
Abstract
Evidence is presented for the formation of products in irradiated dinucleoside monophosphates in which both bases are damaged. The dinucleoside monophosphates d(GpT), d(GpC), d(TpG) and d(CpG) were X-irradiated in oxygenated aqueous solution. Product identification was by NMR spectroscopy. In products containing double base lesions, guanine is converted to 8-hydroxyguanine and the pyrimidine base is degraded to a formamido remnant.
摘要
有证据表明，在经辐照的单磷酸二核苷中会形成两个碱基均受损的产物。单磷酸二核苷d(GpT)、d(GpC)、d(TpG)和d(CpG)在含氧水溶液中进行X射线辐照。通过核磁共振光谱法进行产物鉴定。在含有双碱基损伤的产物中，鸟嘌呤转化为8-羟基鸟嘌呤，嘧啶碱基降解为甲酰胺残基。
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