Weiss D W
Natl Cancer Inst Monogr. 1976 Nov;44:115-22.
Neoplasia is considered within the biologic framework of host-parasite relationships, and the arguments favoring this perspective are discussed. By viewing neoplastic processes as dynamic interactions between transformed clones, host defense mechanisms, and the environmental circumstances impinging directly on the neoplastic event, the experimentalist and clinician are better prepared conceptually for a balanced assessment of all factors determining the development and outcome of confrontations with neoplastic clones. The frame of reference placing progressive neoplasia into the category of host-parasite associations also prepares the ground for techinical approaches to the study and observation of oncologic phenomena appropriate to their essential nature. The correct evaluation and most promising future development of the current emphasis on immunologic parameters of neoplasia demands especially an awareness of the role of immunologic variables in other host-parasite relationships.
肿瘤形成是在宿主 - 寄生虫关系的生物学框架内进行考量的，同时也讨论了支持这一观点的论据。通过将肿瘤形成过程视为转化克隆、宿主防御机制以及直接影响肿瘤事件的环境因素之间的动态相互作用，实验人员和临床医生在概念上能更好地为全面评估所有决定与肿瘤克隆对抗的发展和结果的因素做好准备。将进行性肿瘤归为宿主 - 寄生虫关联类别的参考框架，也为以适合肿瘤现象本质的技术方法来研究和观察肿瘤现象奠定了基础。对当前肿瘤免疫参数重点的正确评估及其最有前景的未来发展，尤其需要认识到免疫变量在其他宿主 - 寄生虫关系中的作用。
