McGrath P C
Department of Surgery, University of Kentucky Chandler Medical Center, Lexington 40536-0084.
Semin Surg Oncol. 1994 Sep-Oct;10(5):364-8. doi: 10.1002/ssu.2980100509.
Retroperitoneal sarcomas are rare malignant tumors, accounting for approximately 10-20% of all soft tissue sarcomas. Because of their anatomic location and indolent nature, these tumors are usually quite extensive when first detected with little hope of improvement in the early detection rate. Improved survival rates will therefore depend on obtaining better local control through an aggressive surgical approach, making every effort to achieve a complete resection with histologic negative margins, which in most cases will require the resection of adjacent organs or vascular structures. Even with such aggressive surgical approach, continued problems with local recurrence are reported and it is important to follow patients who had undergone surgical resection very carefully in order to identify those who would benefit from reresection. The results of postoperative adjuvant irradiation and/or chemotherapy have so far been discouraging. Until there is a national registry and a national intergroup study to develop strategies and innovative trials for the effective treatment of these tumors, it is unlikely that there will be much improvement in the current survival rates.
腹膜后肉瘤是罕见的恶性肿瘤，约占所有软组织肉瘤的10%-20%。由于其解剖位置和生长缓慢的特性，这些肿瘤首次被发现时通常已经范围相当广泛，早期发现率几乎没有改善的希望。因此，提高生存率将取决于通过积极的手术方法获得更好的局部控制，尽一切努力实现组织学切缘阴性的完整切除，在大多数情况下这将需要切除相邻器官或血管结构。即便采用如此积极的手术方法，仍有局部复发的持续问题报道，对接受手术切除的患者进行非常仔细的随访很重要，以便识别那些将从再次切除中获益的患者。迄今为止，术后辅助放疗和/或化疗的结果一直令人沮丧。在有全国性登记和全国性联合研究以制定有效治疗这些肿瘤的策略和创新试验之前，目前的生存率不太可能有很大改善。
