Midelfart E, Winnem M
Medisinsk avdeling, Glaxo Norway AS, Oslo.
Tidsskr Nor Laegeforen. 1994 Nov 30;114(29):3430-2.
Approximately 5% of the adult Norwegian population suffer from migraine. Sumatriptan is a new anti-migraine drug which has been shown in clinical studies to be efficacious in up to 80% of attacks treated. These early clinical studies have all been carried out at specialist centres and the present study was planned to see if migraine patients treated by general practitioners would also benefit from this new therapy. This placebo controlled, randomized, double blind study was carried out by 50 general practitioners and two neurologists, and included 294 patients. A total of 1,485 migraine attacks were treated. The results show that Sumatriptan is equally efficacious and well tolerated when used to treat patients in general practice as at specialist clinics. Sumatriptan was efficacious in relieving pain and other migraine symptoms in 76% of the migraine attacks treated, while placebo had the desired effect in 29% of attacks.
约5%的挪威成年人口患有偏头痛。舒马曲坦是一种新型抗偏头痛药物,临床研究表明,在接受治疗的发作中,该药对高达80%的患者有效。这些早期临床研究均在专科中心进行,本研究旨在观察由全科医生治疗的偏头痛患者是否也能从这种新疗法中获益。这项安慰剂对照、随机、双盲研究由50名全科医生和两名神经科医生开展,纳入了294名患者。共治疗了1485次偏头痛发作。结果显示,在全科医疗中使用舒马曲坦治疗患者时,其疗效和耐受性与在专科诊所治疗时相当。在接受治疗的偏头痛发作中,76%的发作使用舒马曲坦后疼痛及其他偏头痛症状得到缓解,而安慰剂在29%的发作中产生了预期效果。