Häyry P, Yilmaz S
Transplantation Laboratory, Helsinki University, Finland.
Transplant Proc. 1994 Dec;26(6):3159-60.
The aetiology of chronic rejection is most likely multifactorial. The common feature in all organ allografts undergoing chronic rejection is persistent perivascular inflammation and a concentric generalised arteriosclerosis affecting all first and second order intramural arteries. A hypothesis is presented that low-grade damage to the endothelium induces the secretion of growth factors which, in turn, are responsible for smooth muscle cell replication and their influx into intima.
慢性排斥反应的病因很可能是多因素的。所有发生慢性排斥反应的器官同种异体移植的共同特征是持续性血管周围炎症以及影响所有一级和二级壁内动脉的同心性全身性动脉硬化。本文提出一个假说，即内皮的低度损伤会诱导生长因子的分泌，而生长因子反过来又负责平滑肌细胞的复制及其向内膜的浸润。
