Muolo A, Ghidini O, Tonon M, Galvani E, Baratta P F, Confortini P
Ric Clin Lab. 1976 Jul-Sep;6(3):277-84. doi: 10.1007/BF02899975.
Chronic renal failure in man is associated with a hypergastrinaemia which is not corrected by haemodialysis. Serum gastrin concentrations were measured in 66 patients on maintenance haemodialysis and in 27 patients after successful kidney transplantation. The basal gastrin levels distinguished 2 groups of patients on maintenance haemodialysis: a first group with gastrin values less than or equal to 120 pg/ml (mean 58+/-29.88 pg/ml) and a second group with gastrin values greater than 120 pg/ml (mean 295+/-257 pg/ml). The onset of urine output after kidney transplantation was associated with a dramatic fall in gastrin concentration (3 patients studied in the early post-transplant period). 24 patients with stabilized transplant function had serum gastrin levels less than 120 pg/ml (mean 21.33+/- 17.29 pg/ml). The gastrin response to a standard protein meal depended on the basal gastrin concentration and was different in patients with renal failure on maintenance haemodialysis and those with a successful kidney transplantation.
人类慢性肾衰竭与一种高胃泌素血症相关，这种高胃泌素血症不能通过血液透析得到纠正。对66例维持性血液透析患者和27例肾移植成功后的患者测定了血清胃泌素浓度。基础胃泌素水平将维持性血液透析患者分为两组：第一组胃泌素值小于或等于120 pg/ml（平均58±29.88 pg/ml），第二组胃泌素值大于120 pg/ml（平均295±257 pg/ml）。肾移植后尿量的出现与胃泌素浓度的急剧下降相关（对3例移植后早期患者进行了研究）。24例移植功能稳定的患者血清胃泌素水平小于120 pg/ml（平均21.33±17.29 pg/ml）。对标准蛋白餐的胃泌素反应取决于基础胃泌素浓度，并且在维持性血液透析的肾衰竭患者和肾移植成功的患者中有所不同。
