Korman M G, Laver M C, Hansky J
Br Med J. 1972 Jan 22;1(5794):209-10. doi: 10.1136/bmj.1.5794.209.
Fasting serum gastrin was measured by radioimmunoassay in 89 patients with chronic renal failure. When the serum creatinine level was used as an index of the degree of renal impairment serum gastrin rose proportionately with the degree of renal failure. Haemodialysis did not significantly alter serum gastrin levels but renal transplantation tended to return them towards normal. This study indicates that the kidney has a role in the degradation of gastrin.
采用放射免疫分析法对89例慢性肾衰竭患者测定了空腹血清胃泌素。当将血清肌酐水平作为肾功能损害程度的指标时,血清胃泌素水平随肾衰竭程度成比例升高。血液透析未显著改变血清胃泌素水平,但肾移植往往使其恢复至正常水平。本研究表明,肾脏在胃泌素的降解中发挥作用。