O'Neill T P, Winkler A J, Wu J
Department of Physics, University of Vermont, Burlington 05405.
Ultrasound Med Biol. 1994;20(6):579-88. doi: 10.1016/0301-5629(94)90094-9.
Temperature rise generated by focused ultrasound beams was tested on semipermanent tissue-bone phantoms. The phantoms were capped (sealed) plastic hollow cylindrical containers filled with tissue-mimicking material (TMM), in which were imbedded 25 microns diameter copper-constantan thermocouples (TC) and a piece of compact human or cow bone. The acoustic frequency specific attenuation coefficient of TMM was adjusted to be 0.3 dB cm-1 MHz-1 as specified by the FDA for a frequency range of 1-5 MHz. A high density 0.318 cm thick polyethylene sheet was chosen as the material to make caps of the phantoms. A formula developed to estimate the upper limit of temperature rises at tissue-bone interfaces generated by focused ultrasound has been proved to be appropriate experimentally using the semipermanent phantoms.
在半永久性组织-骨模型上测试了聚焦超声束产生的温度升高。这些模型是加盖（密封）的塑料空心圆柱形容器，里面装满了组织模拟材料（TMM），其中嵌入了直径25微米的铜-康铜热电偶（TC）和一块致密的人骨或牛骨。按照美国食品药品监督管理局（FDA）对1-5 MHz频率范围的规定，将TMM的声频比衰减系数调整为0.3 dB cm-1 MHz-1。选择了一种高密度、0.318厘米厚的聚乙烯片材作为制作模型盖子的材料。通过使用这些半永久性模型进行实验证明，一个用于估算聚焦超声在组织-骨界面产生的温度升高上限的公式是合适的。
