Pawlowski T J, Staerz U D
Dept. of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
Behring Inst Mitt. 1994 Jul(94):94-103.
Thymus-derived (T) lymphocytes have the potential to express antigen receptors (TCR) that can recognize both self, as well as foreign antigens as they appear on the cell surface. In the thymus, positive selective allows the maturation of T cells that are able to see foreign antigens in conjunction with molecules encoded by genes of the major histocompatibility complex (MHC), whereas negative selection deletes auto-aggressive T cells. Control of T cell development is the only known function of the thymus. Therefore, it has been argued that recognition events responsible for selection of the T cell repertoire are guided by unique cellular interactions in the thymus. Here, we will show that positive selection can also occur on non-thymic cells. We will also argue that positive selection is not dependent on unique thymic accessory cells (AC) function. In other words, restricted recognition is not taught rather thymocytes learn it by themselves.
胸腺来源的（T）淋巴细胞有潜力表达抗原受体（TCR），这些受体能够识别细胞表面出现的自身抗原以及外来抗原。在胸腺中，阳性选择允许能够识别与主要组织相容性复合体（MHC）基因编码的分子结合的外来抗原的T细胞成熟，而阴性选择则清除自身攻击性T细胞。胸腺的唯一已知功能是控制T细胞发育。因此，有人认为负责选择T细胞库的识别事件是由胸腺中独特的细胞相互作用引导的。在这里，我们将表明阳性选择也可以在非胸腺细胞上发生。我们还将论证阳性选择不依赖于独特的胸腺辅助细胞（AC）功能。换句话说，限制性识别不是被教导的，而是胸腺细胞自己学会的。
